2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid
PS210
CAS: 1221962-86-2
Molecular Formula: C19H15F3O5
2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid - Names and Identifiers
2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid - Physico-chemical Properties
| Molecular Formula | C19H15F3O5 |
| Molar Mass | 380.31 |
| Density | 1.400±0.06 g/cm3(Predicted) |
| Boling Point | 577.9±50.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 2.93±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | PS210 is a substrate-selective inhibitor of protein kinase PDK1. It acts by binding to the PIF-pocket allosteric docking site. |
| Target | PDK1 : ic50 （kd）3 μM |
2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid - Reference
| Reference Show more | 1: Schelhorn C, Martín-Malpartida P, Suñol D, Macias MJ. Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation. Sci Rep. 2015 Oct 12;5:14990. doi: 10.1038/srep14990. PubMed PMID: 26456073; PubMed Central PMCID: PMC4601027. 2: Busschots K, Lopez-Garcia LA, Lammi C, Stroba A, Zeuzem S, Piiper A, Alzari PM, Neimanis S, Arencibia JM, Engel M, Schulze JO, Biondi RM. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21;19(9):1152-63. doi: 10.1016/j.chembiol.2012.07.017. PubMed PMID: 22999883. 3: Tomizawa K, Omori A, Ohtake A, Sato K, Takahashi M. Tau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tau. FEBS Lett. 2001 Mar 16;492(3):221-7. PubMed PMID: 11257498. |
2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.63 ml | 13.148 ml | 26.295 ml |
| 5 mM | 0.526 ml | 2.63 ml | 5.259 ml |
| 10 mM | 0.263 ml | 1.315 ml | 2.63 ml |
| 5 mM | 0.053 ml | 0.263 ml | 0.526 ml |
Last Update：2024-01-02 23:10:35
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